Category Medical and Illnesses

Aug 7 2022

Multisystem inflammatory syndrome in children (MIS-C) does NOT justify (at all!) their vaccination against SARS-CoV-2


Geert Vanden Bossche, DVM, PhD General Manager at Voice for Science and Solidarity | The biggest challenge in vaccinology: Countering immune evasion originally published on TS News on Aug. 5, 2022

MIS-C is a disease that may occur in school-age children two to six weeks after infection with SARS-CoV-2 (SC-2) virus. MIS-C is a post-infectious inflammatory condition which typically occurs after asymptomatic/mild SC-2 infection. Some children may need hospitalization because of inflammatory reactions in different organs. While the syndrome can be serious, the absolute risk for MIS-C is very low (about 6.5 per 100 000 person-years) and known to be increased in boys aged 5-11 years with foreign-born parents, asthma, obesity, and life-limiting condition (https://www.thelancet.com/action/showPdf?pii=S2666-7762%2822%2900137-5). 
MIS-C mostly resolves within a few days after timely and adequate (immunosuppressive) treatment. As the pandemic evolves and more infectious Omicron (sub)variants are now dominating the scene, MIS-C is occurring less frequently and with diminished severity of disease (https://jamanetwork.com/journals/jama/fullarticle/2792718). This evolution cannot be entirely explained by C-19 vaccination of young children as vaccine coverage rates in this age group are still very low (15% and 3% as recently reported in studies from Israel and the US, respectively; https://jamanetwork.com/journals/jama/fullarticle/2792718; https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac471/6605071).
It is therefore tempting to speculate that enhanced viral infectiousness and transmission significantly contribute to dampening the incidence rate and severity of MIS-C in young children. This suspicion is supported by a previous study in which the authors speculated that some of the risk factors they identified for MIS-C could be associated with enhanced disease transmission (e.g., in children with foreign-born parents or explaining the shift in age from 12-15 years down to 5-11 years amongst children with MIS-C throughout the pandemic (https://www.thelancet.com/action/showPdf?pii=S2666-7762%2822%2900137-5). 

To better understand the origin of the disease, and why children in particular are susceptible to contracting MIS-C, it is important to understand how the child’s innate immune system is educated and trained to combat infections with glycosylated viruses causing acute self-limiting viral infection (ASLVI; e.g., SC-2) or acute self-limiting viral disease (ASLVD).

The child’s innate immune system first learns to discern relevant pathogen-derived molecular patterns and discriminate them from self-derived motifs. Once the child’s natural killer (NK) cells have been  ‘educated[1]’ (pre-primed) to adequately sense and distinguish pathogen-derived self-mimicking peptides (PSMPs) from  self-derived self-mimicking peptides, presentation thereof in high density patterns may trigger epigenetic changes that imprint these NK cells with memory (so-called ‘training’ of NK cells). 

In young children who have cleared their maternal antibodies (around the age of 6 months), abundantly produced innate (sometimes called ‘natural’) antibodies (Abs) play a critical role in initiating active use of their own immune system. In these children, innate Abs are tasked with recognizing and binding free-circulating self-derived glycan motifs (e.g., decorating foreign-derived  [including pathogen-derived] or self-derived proteins) to potentiate[2] the presentation of repetitive patterns of foreign- or self-derived self-mimicking peptides on the surface of autologous somatic cells or antigen (Ag-)presenting cells (APCs). Glycosylation of self-proteins is an important mechanism for inducing T cell-mediated peripheral tolerance[3] and, not surprisingly, mimicked by several pathogens (e.g., glycosylated viruses) as a strategy to subvert the host immune system. As they decorate themselves with self-mimicking patterns of self-glycans, glycosylated viruses (e.g., corona virus [CoV], influenza virus, respiratory syncytial virus [RSV], measles, mumps, rubella, varicella virus,…) can be recognized and captured by innate Abs and thereby contribute to educating the child’s innate immune effector cells (i.e., NK cells).

As the child grows up, the functional capacity of their innate Abs gradually declines so that their immune system can progressively replace the ‘self’-sensing innate Ab capacity by a pool of pre-primed NK cells that can recognize pathogen-derived self-mimicking (i.e., ‘altered self’) motifs on virus-infected or otherwise pathologically altered host cells such as to kill those cells.
For as long as a child possesses an abundant functional capacity of innate Abs, glycosylated pathogens and self-ligands will be complexed by innate Abs to educate NK cells on how to distinguish ‘self’ from ‘non-self’.  This is how the innate immune system of the young child is thought to ‘adapt’ to the early-life extra-maternal environment where it must learn to rapidly sense peptide motifs that differ from self-peptides. This would enable NK cells to target and kill autologous host cells that are decorated with such ‘altered self’ peptides (e.g., infected, or otherwise pathologically altered host cells). 

Once NK cells are educated, the NK cell training process dictates their functional re-programming (https://www.frontiersin.org/articles/10.3389/fimmu.2018.01869/full). Training is thought to result from epigenetic alterations that are triggered by changes in the SC-2 infectious landscape and generate ‘adaptive’ or ‘memory-like’ NK cells. Adequate training of its first line of immune defense enables the child to mount protective natural immunity against SC-2 (and other glycosylated viruses/ pathogenic agents sharing the same PSMPs[4]) upon future exposure. This can already explain why prophylactic childhood vaccinations using live attenuated virus are very efficient at inducing natural immunity against measles, mumps, rubella, varicella and generating herd immunity−it’s only when they become infected with an antigenically ‘shifted’ (i.e., very different) variant that individuals who acquired natural immunity can still contract disease due to ADEI.  

However, depending on viral infectious pressure, it is perfectly possible, even for a young and healthy child, to become susceptible to productive infection upon exposure to glycosylated, ASLVI-enabling viruses that do not normally cause symptomatic infection in young children.

When young and healthy children become infected during an outbreak of a virus with a relatively low reproduction number (R0; e.g., infection with common cold coronavirus [CoV] or seasonal Flu; R0 < 2.5), they almost always develop asymptomatic or very mild infection. However, dominant circulation of more infectious CoV or Influenza virus variants can occasionally provoke cases of severe disease in children. It is reasonable to postulate that enhanced viral infectiousness raises the chance for a person to become re-infected shortly after a previous course of asymptomatic infection. This will increase the likelihood that immature, short-lived Ag-specific Abs[5] of relatively low affinity, which typically develop after asymptomatic/ mild infection, will still be present when that person becomes re-exposed to the virus. Because of their Ag-specificity, these Abs may outcompete the child’s innate polyspecific IgM Abs, which have an even lower affinity for the protein Ag that is responsible for initiation of infection (i.e., spike [S] protein in the case of CoV). Depending on their titer, these non-neutralizing, Ag-specific Abs can therefore prevent or at least diminish binding of innate Abs to the virus. Although these short-lived Abs cannot neutralize the virus, they can bind to it and enhance its infectiousness.

This is particularly problematic in young children as insufficient training of their NK cells prevents effective immune targeting of SC-2-infected cells expressing virus-derived self-mimicking peptides on their surface. NK cells that are largely ‘pathogen-inexperienced’ together with enhanced SC-2 infectiousness would entail enhanced susceptibility of young children to SC-2 infection (i.e., so called ‘Ab-dependent enhancement of viral infectiousness’; ADEI). Hence,  re-infection shortly after previous asymptomatic exposure will likely allow the virus to break through the cell-based innate immune system of young children and could potentially cause (severe) disease (https://pubmed.ncbi.nlm.nih.gov/33391280/).
However, as these post-infectious Abs wane rapidly (they are no longer detectable at about 8 weeks), only a limited number of children will become re-exposed to the circulating virus shortly after their previous productive exposure. This already explains why most cases of MIS-C occur between 2 and 6 weeks (on average 4 weeks) after the previous asymptomatic/ mild infection, presumably depending on the titer of the infection-enhancing Abs at the timepoint of re-exposure. It is therefore not surprising to also observe high variability in the severity of MIS-C disease. 

More infectious SC-2 variants may enable stronger stimulation of NK cells and thereby readily prime NK cell effector responses in young children; alternatively, more infectious SC-2 variants could increase the likelihood for viral re-exposure to occur in the presence of a relatively higher titer of infection-enhancing anti-S Abs. Both phenomena are likely to reduce the risk of MIS-C in young children. 

After many years of NK cell vaccine research (which I was unable to publish for intellectual property  reasons), I determined that the recruitment on MHC class I molecules of PSMPs into ‘non-self’ high-density arrays (situated outside of the MHC class I peptide-binding groove!) is what allows for activation and epigenetic imprinting (i.e., training) of cytotoxic NK cells that are capable of killing host cells that present such PSMPs on their surface (for example as a result of viral infection).
I postulate that strong stimulation by enhanced viral infectiousness could even obviate the need for cumulative triggering of NK cells (so-called ‘training’) in order for NK effector cells to become imprinted with memory. NK cells that have acquired a memory-like phenotype could readily eliminate host cells that are infected with relevant glycosylated pathogens. Enhanced viral infectiousness in the young child could allow productive SC-2 infection even in the presence of innate Abs and thereby enable ‘power training’ of pre-primed NK cells. Even though symptoms could still be mild, productive infection would have the capacity to substitute a single ‘power training’ event for regular, incremental training of functional NK cell responsiveness to pathogen-derived ligands. 
As full-fledged NK cell ‘priming’ towards PSMPs would therefore improve with enhanced viral infectiousness, C-19 unvaccinated children (and even some adolescents) who recently contracted mild disease would be equipped with innate immune memory while no longer developing infection-enhancing anti-S Abs (as shown in fig. 1). Alternatively, enhanced viral infectiousness leads to higher viral infection rates and thereby shortens the average time window for a person to become re-exposed after a previous asymptomatic SC-2 infection. A shortened window for re-exposure makes it more likely that the latter occurs in the presence of a relatively high titer of infection-enhancing Abs. It is not unreasonable to assume that the mechanism of naturally induced infection-enhancing Abs is similar to the one previous described for vaccine-induced anti-S Abs−a high enough concentration of these Abs would allow a subset of these Abs to bind to SC-2 virions tethered to dendritic cells and thereby exert a disease-mitigating effect (https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic + fig. 2).  

Based on the rationale explained above, one could easily understand how the prolonged C-19 pandemic and the enhanced frequency of repetitive waves of more infectious variants (e.g., Omicron) is likely to have a ‘power training’ effect on relevant NK cells of young C-19 unvaccinated children developing mild primary infection (i.e., overlapping with abundant functional capacity of innate Abs) or to provide a strong disease-mitigating adaptive immune response in those who recently contracted asymptomatic SC-2 infection. The latter would be protected from severe and even moderate disease by virtue of infection-enhancing Abs and cytotoxic CD8+ T cells, respectively (as illustrated in fig. 2). A further increase in viral infectiousness would not make young, previously asymptomatically infected children more susceptible to disease but rather increase their likelihood to develop productive SC-2 infection and generate effector memory NK cells or further expand those (as shown by the arrows in green in fig. 1).
With this understanding, it is not surprising that the advent of Omicron (sub)variants has led to a rapidly regressing incidence rate and severity of MIS-C (https://jamanetwork.com/journals/jama/fullarticle/2792718).

How does mass vaccination affect the child’s susceptibility to SC-2 infection?

As the mass vaccination program during this pandemic has led to the dominant circulation of more infectious SC-2 variants, it is not surprising to find that a few, young (C-19 unvaccinated) children contracted MIS-C and even needed hospitalization—this was an extremely rare event at the beginning of the pandemic. However, the mass vaccination program has provided immune escape variants characterized by a higher level of intrinsic viral infectiousness (e.g., of the delta variant) with a competitive advantage. The ensuing higher infection rate in the population (and in households!) therefore came with an additional likelihood for young children to become re-infected shortly after their previous asymptomatic infection. As previously described, the incidence rate of MIS-C is now waning as a result of enhanced innate immune training and mitigation of (severe) disease by more and more infectious SC-2 variants that have now become dominant. 

Vaccinating children against SC-2 is a colossal scientific blunder with potentially disastrous health consequences 

Parents should be adequately briefed about early signs and symptoms of MIS-C (https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/misc-and-covid19-rare-inflammatory-syndrome-in-kids-and-teens) as the prognosis is very favorable upon timely and adequate treatment. However, the consequences of vaccinating young children with these replication-incompetent C-19 vaccines will be an unforgivable sin that will only lead to hospitalization and mortality rates that dwarf those highest observed for MIS-C (https://www.trialsitenews.com/a/intra-pandemic-vaccination-of-toddlers-with-non-replicating-antibody-based-vaccines-targeted-at-aslvi1-or-aslvd2-enabling-glycosylated-viruses-pr-66e8b959; https://www.trialsitenews.com/a/epidemiologic-ramifications-and-global-health-consequences-of-the-c-19-mass-vaccination-experiment-a212bb47).

Notwithstanding the fact that these vaccines may–FOR NOW (!)–still protect against (severe) disease from SC-2 as well as from other ASLVI- or ASLVD-enabling glycosylated pathogens (https://www.trialsitenews.com/a/vaccination-of-vulnerable-groups-against-monkeypox-virus-mpv-in-a-highly-c-19-vaccinated-population-will-drive-adaptive-evolution-of-mpv-and-ignite-2db3eac6), enhanced adsorption or internalization of more infectious Omicron (sub) variants (e.g., BA.4, BA.5 and BA.2.12.1) onto or into tissue-resident dendritic cells dampens presentation of other, pathogen-derived antigens by these professional APCs while exhausting CD8+ T cells (as illustrated in fig. 2). This is highly likely to diminish the child’s immune defense against a multitude of microbial glycosylated pathogens and prevent peripheral tolerance, thereby putting them at higher risk  of contracting immunopathologies (https://www.trialsitenews.com/a/epidemiologic-ramifications-and-global-health-consequences-of-the-c-19-mass-vaccination-experiment-a212bb47).

More importantly, the currently circulating Omicron (sub)variants are already endowed with higher intrinsic virulence that–for now–is still kept in check by the virulence-inhibiting activity of infection-enhancing anti-S Abs (as reviewed in: https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic). We have already witnessed how more infectious variants developed resistance to potentially infection-neutralizing Abs induced by C-19 vaccines and there is little doubt that more virulent SC-2 lineages will manage a similar ‘trick’ to develop resistance to potentially virulence-‘neutralizing’ Abs (especially since repeated exposure to more infectious circulating Omicron (sub)variants will recall these vaccinal S-specific Abs and thereby ensure sustained immune pressure). When this happens, vaccinated infants and toddlers will be left with an adaptive immune system that does no longer protect them from severe C-19 disease and with NK cells that have not been trained due to prolonged suspension of their education (https://www.trialsitenews.com/a/intra-pandemic-vaccination-of-toddlers-with-non-replicating-antibody-based-vaccines-targeted-at-aslvi1-or-aslvd2-enabling-glycosylated-viruses-pr-66e8b959). Prolonged sidelining of the child’s innate Abs is thought to hamper the functional capability of cytotoxic NK effector cells to sense and target virus-derived, molecular self-mimicking peptides that are expressed on virus-infected host cells. As already reported, lack of innate immune education could dramatically impede the child’s capacity to generate natural immunity to SC-2 in particular as well as other ASLVI- or ASLVD-enabling glycosylated viruses in general (https://www.trialsitenews.com/a/epidemiologic-ramifications-and-global-health-consequences-of-the-c-19-mass-vaccination-experiment-a212bb47).

On the other hand, diminished complexation of foreign glycosylated ligands by innate Abs could render NK cells that lack self-MHC-I inhibitory receptors hyporesponsive to stimulatory receptor activation as a result of their chronic low-level stimulation by self-derived peptides. Because of the resulting diminished threshold of NK cell activation in the periphery, young C-19 vaccinated children would be prone to developing immunopathologies.
However, in the likely event that resistance to potentially virulence-‘neutralizing’ Abs develops, it can be expected that−given the high SC-2 infection rate− C-19 vaccinated infants and toddlers will primarily succumb to Ab-dependent enhancement of severe C-19 disease rather than to severe disease from any other circulating ASLVI or ASLVD or from immunopathology.   

Conclusion

Increased SARS-CoV-2 exposure results from dominant expansion of more infectious SC-2 variants, a phenomenon undeniably caused by the C-19 mass vaccination program. As suggested by the results from earlier studies, increased exposure to SC-2 together with a number of predisposing factors renders very few young children susceptible to developing MIS-C following a recent asymptomatic infection (https://www.thelancet.com/action/showPdf?pii=S2666-7762%2822%2900137-5).
There is no doubt that vaccinating children against SC-2 is a colossal blunder and merely places the child at high risk of severe health damage. MIS-C has not only a low incidence (which is further declining) but can also be successfully treated using conventional drug therapy. This contrasts with the protective effect of C-19 vaccination against MIS-C, which is temporary and leaves the young child at high risk of contracting Ab-dependent enhancement of severe disease upon future exposure to new SC-2 variants (which will dominantly emerge as a result of the current population-level immune pressure on viral virulence).
It is critical to understand that the high viral infection rate in highly C-19 vaccinated populations due to mass vaccination, rather than a lack of C-19 vaccination, is responsible for this phenomenon. There is therefore no single scientific rationale for vaccinating children against SC-2−exactly the contrary is true: C-19 vaccination of young children is highly likely to not only provoke a soaring incidence of severe disease and mortality due to immunopathology and other microbial diseases but ultimately also due to SC-2. 
Public health authorities are creating the illusion for parents that C-19 vaccines will protect their children, instead of educating them how to recognize early signs and symptoms of MIS-C in order to seek highly effective treatment for their child in due time. In addition, they seem to ignore that preserving natural immunity in young children is critical as it is the key pillar of herd immunity to ASLVIs, including SC-2.

Figures

Fig. 1: Upon exposure to more infectious SC-2 variants, young children may develop MIS-C as a result of re-exposure shortly after previous asymptomatic infection. However, as their infectiousness increases, new SC-2 variants may break through the child’s innate Ab-mediated protection and thereby cause mild infection that imprints its NK cells with memory and therefore dramatically boosts the child’s first line of immune defense. Alternatively, more infectious variants enable re-exposure in the presence of higher titers of short-lived infection-enhancing anti-S Abs. In the latter case, young children are protected from severe disease presumably because a subset of anti-S Abs can bind to SC-2 virions tethered to dendritic cells (see fig. 2), thereby inhibiting severe/systemic disease whereas sustained activation of CTLs (as a result of the infection-enhancing capacity of these Abs upon their binding to free virions) further mitigates C-19 disease. Both scenarios may be responsible for the observed reduction in the incidence rate and severity of MIS-C as the pandemic continues to evolve (indicated by “–“ and arrows in blue). Since the pandemic has now evolved highly infectious SC-2 variants (i.e., the new Omicron [sub]variants), viral exposure of young children is more and more likely to readily cause mild infection resulting in NK cell ‘power training’ and further expansion of effector memory NK cells upon a further increase in viral infection rates (indicated by “+” and arrows in green). This may ultimately prevent young children from developing MIS-C all together.  

Fig. 2 (from https://www.trialsitenews.com/a/epidemiologic-ramifications-and-global-health-consequences-of-the-c-19-mass-vaccination-experiment-a212bb47):
Acute, self-limiting viral infections that don’t lead to systemic/severe disease (and possibly death) are terminated by M(ajor) H(istocompatibility) C(omplex)-unrestricted, cytotoxic CD8+ T cells that have no memory and the activation of which is triggered by a universal, pathogen-nonspecific Tc epitope comprised within the spike (S) protein. Unless an infected person progresses to developing severe disease, this is what allows a fairly rapid recovery from disease after primary productive infection (and certainly before fully functional virus-neutralizing Abs peak) [according to 2a-2b-2c-2d pathway]. However, rather than stimulating de novo generation of new neutralizing Abs towards variants that escaped the neutralizing activity of vaccine-induced Abs, exposure of vaccinees to these immune escape variants will rapidly boost their declining titers of non-neutralizing, infection-enhancing Abs (those are directed against an antigenic site that is conserved within the N-STD of all SC-2 variants and has therefore a license to commit ‘antigenic sin’ once it has primed the host’s immune system).

In vaccinees with poor experience in fighting productive infection (and hence, poor training of their innate immune defense according to pathway 1a-1b-1c) prior to C-19 vaccination, infection-enhancing Abs[6] that are responsible for preventing severe disease by binding to DC-tethered virus (according to 3a-3b-3c-3d pathway) can synergize with strongly activated cytotoxic CD8+ Tc-mediated killing (3c’) to even prevent C-19 disease all together and hence, render vaccinees asymptomatic despite their high susceptibility to re-infection (B + C ?  D). As prevention of disease is not due to prevention of productive infection but to accelerated abrogation of infection, these vaccinees will continue to shed and transmit SC-2 upon re-infection.  Whereas innate immune effector cells are MHC-unrestricted and polyspecific (i.e., NK cells) and, therefore, don’t drive immune escape, the infection-enhancing-Abs are Ag-specific (i.e., S-specific) and – if produced at high enough titers and with high enough affinity by a large part of the population – will promote natural selection of immune escape variants that can resist  the virulence-inhibiting capacity of these Abs. This is because vaccinees cannot prevent productive viral infection; consequently, the immune pressure they exert on viral virulence is suboptimal in that it cannot prevent the expansion in prevalence of immune escape SC-2 variants that have the capacity to overcome this immune pressure. Resistance of viral variants to the virulence-inhibiting activity of infection-enhancing Abs will inevitably cause Ab-dependent enhancement of severe disease (ADESD).  




1.  Education of NK cells that lack self-MHC-I inhibitory receptors but are endowed with germline-encoded NK cell activation receptors dictates their functional capability to recognize self- or pathogen-derived self-mimicking ligands and mediate innate effector functions; https://www.frontiersin.org/articles/10.3389/fimmu.2018.01869/full

2.  Besides their neutralizing activity, natural/innate Abs can, indeed, serve as immune potentiators (‘natural
adjuvants’) to upregulate the presentation of antigens on cell surface-expressed MHC class I molecules
https://pubmed.ncbi.nlm.nih.gov/14502281/)

3.  https://onlinelibrary.wiley.com/doi/full/10.1038/icb.2008.48;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966069/

4.  Enveloped glycosylated viruses are critical to educate the child’s innate immune system in ways that allow
recognition and elimination of somatic cells expressing PSMPs (as a result of viral infection or other pathologic
alteration) which may otherwise induce tolerance (e.g., cancer cells) or provoke autoreactive or immune
inflammatory responses (i.e., causing autoimmune or hyperinflammatory disease, respectively).

5.  i.e., ‘spike protein-specific’ in case of SC-2

6.  As previously explained, the non-neutralizing, infection-enhancing Abs are currently hampering trans infection at the level of distant organs such as the lower respiratory tract; this is what’s currently exerting population-level immune pressure on viral virulence: https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic).

Aug 5 2022

COVID Vaccine Lawsuits Begin


Armstrong Economics Blog/Disease Re-Posted Aug 5, 2022 by Martin Armstrong

NorthShore University HealthSystem in Chicago was sued by a nonprofit religious organization called Liberty Counsel. The group claims that NorthShore violated workers’ religious autonomy by dismissing religious exemptions and forcing all workers to receive the COVID-19 vaccine. NorthShore was in the wrong and decided to settle for $10,337,500.

Over 500 current and past employees will receive a payout, and the group will notify others of the lawsuits and give them the option to submit a claim. “NorthShore will also change its unlawful ‘no religious accommodations’ policy to make it consistent with the law, and to provide religious accommodations in every position across its numerous facilities,” Liberty Counsel stated.

Other groups will follow suit. They may have granted the pharmaceutical companies immunity, but there was a grey area for employers. Countless people lost their jobs due to the vaccine mandate, which likely was a violation of the Constitution.

Lawsuits may begin with large corporations, but if the Republicans regain control, health agencies and government officials may be investigated as well. This lawsuit is a major win for medical autonomy as companies will be less likely to comply with government mandates as they now know they could risk legal retaliation.

Aug 3 2022

Joe Biden Announces White House Monkeypox Response Team to Deliver “Health Equity to all Monkeypox Stakeholders”


Posted originally on the conservative tree on August 2, 2022 | sundance

I was unaware that monkeypox was an issue for the White House. However, today the Biden administration is proud to present a team of government officials tasked for the purpose of handling the whole of government response to the U.S. outbreak of monkeypox.

Additionally, I’m not exactly sure what a “stakeholder in monkeypox” is, but this team is in charge of making sure they have “health equity.”

WHITE HOUSE – “Today, President Biden named FEMA’s Robert Fenton as the White House National Monkeypox Response Coordinator and Dr. Demetre Daskalakis as the White House National Monkeypox Response Deputy Coordinator. Fenton and Daskalakis will lead the Administration’s strategy and operations to combat the current monkeypox outbreak, including equitably increasing the availability of tests, vaccinations and treatments.

[…]  “Bob Fenton and Dr. Daskalakis are proven, effective leaders that will lead a whole of government effort to implement President Biden’s comprehensive monkeypox response strategy with the urgency that this outbreak warrants,” said Anthony Fauci, Chief Medical Advisor to the President. “From Bob’s work at FEMA leading COVID-19 mass vaccination efforts and getting vaccines to underserved communities to Demetre’s extensive experience and leadership on health equity and STD and HIV prevention, this team will allow the Biden Administration to further accelerate and strengthen its monkeypox response.”

Fenton and Daskalakis will coordinate and manage response efforts across the White House and all Federal departments and agencies. They will work with local, state, national, and international stakeholders on tracking and fighting the spread of monkeypox, with state and local partners to ensure they have adequate supplies to test, treat and vaccinate at-risk individuals, with clinicians and providers on available testing, treatment and vaccination options, and with stakeholder communities on building public understanding of the virus and how to address it most effectively.

[…] Over the coming weeks, under the leadership of Fenton and Daskalakis, the Administration will advance and accelerate the United States’ monkeypox response to mitigate the spread of the virus, protect individuals most at risk of contracting the virus, and care for those who have been afflicted with it.” (read more)

Jul 31 2022

Double Vaxxed, Double Boosted, Loaded with Paxlovid, Joe Biden Gets COVID Again


Posted originally on the conservative tree house on July 30, 2022 

Well, isn’t that convenient.   Sorry folks, I can’t come out and take questions, I’ve got the Rona again.

[SOURCE]

Only the second thing that has been positive during his tenure.

[Source Link pdf]

Jul 24 2022

Canada Joins the Netherlands in Operation Eat Bugs, Justin Trudeau Demands 30% Reduction in Nitrogen Farm Emissions


Posted originally on the conservative tree house on July 23, 2022 | sundance

You will switch to bugs, and you will like it.  After using government incentives and subsidies to build a new facility in London, Ontario, to manufacturer 9,000 metric tons of crickets for human consumption to replace cows, pigs and chickens, Canadian Prime Minister Justin Trudeau now triggers a series of nitrogen emission reduction regulations to target traditional farming.

Prime Minister Justin Trudeau is following the same roadmap as his political friend in the Netherlands, Dutch Prime Minister Mark Rutte, and the Canadian farmers are not happy about it.

CANADA – Saskatchewan and Alberta Ministers of Agriculture are expressing profound disappointment in the federal government’s fertilizer emissions reduction target.

“We’re really concerned with this arbitrary goal,” Saskatchewan Minister of Agriculture David Marit said. “The Trudeau government has apparently moved on from their attack on the oil and gas industry and set their sights on Saskatchewan farmers.”

“This has been the most expensive crop anyone has put in, following a very difficult year on the prairies,” Alberta Minister of Agriculture Nate Horner said. “The world is looking for Canada to increase production and be a solution to global food shortages. The Federal government needs to display that they understand this. They owe it to our producers.”

Fertilizer emissions reduction was not even a topic on the agenda of the annual meeting of Federal-Provincial-Territorial ministers of agriculture, who just finished 3 days of meetings in Saskatchewan. Provinces pushed the federal government to discuss this important topic, but were disappointed to learn that the target is already set. The commitment to future consultations are only to determine how to meet the target that Prime Minister Trudeau and Minister Bibeau have already unilaterally imposed on this industry, not to consult on what is achievable or attainable. (read more)

You will shut up, you will stop farming, and you will eat the bugs.

Another press release from the affected Fertilizer industry reads:

[…] “In initial conversations with Agriculture and Agri-Food Canada (AAFC), the government has stated their intention to pursue an absolute emissions reduction of 30%, rather than an emissions intensity reduction of 30%. This short-sighted approach to reducing emissions will result in the need to reduce nitrogen fertilizer use and will have considerable impact on Canadian farmers’ incomes and reduce overall Canadian exports and GDP.” (SEE MORE)

On the positive side, there is no indication yet, that Mexican President Andres Manuel Lopez-Obrador (AMLO) is in alignment with the Canadian proposals for farming.   Trudeau and his uber-leftists might be able to destroy the Canadian farmland; and there is a possibility Joe Biden might join Canada in trying to destroy U.S. farmland; however, it looks like Mexico is going to remain with the commonsense and pragmatic approach outside the western alliance idiocy.

You know we have walked through the looking glass when our minds turn to Mexico as a line of defense against globalist quackery and multinational corruption. Gasoline in Mexico is $3.12/gal.  Gasoline in the United States is $4.78/gal, AMLO explains why HERE.

Jul 19 2022

Fauci Set to Retire


Armstrong Economics Blog/Corruption Re-Posted Jul 19, 2022 by Martin Armstrong

Dr. Anthony Fauci, Mr. COVID himself, announced that he would retire at the end of Joe Biden’s term. Fauci hinted in an interview that he fears an investigation into his personal dealings if the conservatives take back control next year. “They’re going to try and come after me, anyway. I mean, probably less so if I’m not in the job,” Fauci told Politico. We know the vaccination does not work and causes more harm than good. The long-term effects of the vaccines and lockdowns are now coming to light, and Fauci is responsible as the mascot for the entire COVID agenda.

Fauci maintains that boosters will be necessary every year, similar to the flu vaccine, despite the components of the two vaccines differing drastically. Fauci also admitted that the people are waking up to the fear-mongering and brainwashing techniques he used to scare the world to stay inside.

“It’s becoming more and more difficult to get people to listen, because even the people who are compliant want this behind them,” Fauci said, bewildered that people do not obey his every word. “What I try to convince them [of], with my communication method, is we’re not asking you to dramatically alter your lifestyle. We’re not asking you to really interfere with what you do with your life. We’re just asking you to consider some simple, doable mitigation methods.”

The ”simple, doable mitigation methods” involved involuntary house arrest, school closures, business closures, and forced vaccinations of an EXPERIMENTAL mRNA gene-altering therapy. These policies were a gut punch to the global economy. Countless people lost their jobs and lives due to his warped God-complex view of “trust the science.” This man should be held accountable for the damage he has done to society – permanent damage that will linger for generations to come.

Jul 11 2022

The Disease Cycle


Armstrong Economics Blog/Disease Re-Posted Jul 11, 2022 by Martin Armstrong

QUESTION: Marty, You have forecasted that your disease model turned up here in 2022. COVID was exploited, but it was no worse than the flu. Then there is monkeypox. But the latest is the much more lethal Marburg virus in Africa. Is this going to be the real one?

DC

ANSWER: The model did not target a specific virus. There are serious outbreaks throughout history but they are not always the same virus or bacteria. The history of this particular virus only goes back to 1967. This particular virus has a base cycle of 5-year intervals. The major outbreak was 2004-2005 which lasted into 2008. Ideally, our model projected that would reappear in 2013 and it showed up in 2012 a little ahead of schedule.

A major outbreak should come in the 2027-2028 time period. But keep in mind that this has not turned into a pandemic and has been confined to Africa. It is spread through bodily fluids so which usually involves sex or touching an open sore. So I would not be concerned that this will spread to your neighborhood without human intervention. The most devastating disease cycle will be from 2027 into 2050.

Jul 6 2022

The immuno-epidemiological consequences of the mass vaccination experiment – summary


By Geert Vanden Bossche Published originally on Voice for Science and Solidarity on July 4th 2022

Dear all,

For the past two weeks I have been working on a document summarizing my conclusions on the immuno-epidemiological consequences of the mass vaccination experiment.

The result of this is even more frightening than I had predicted. I’ve, therefore, appended a summary of my manuscript by way of ‘tsunami warning’.  

In a nutshell, here is what I am 100% certain of:

The current SC-2 pandemic is still expanding as it is a pandemic of ‘more infectious’ variants and is thus enhancing the susceptibility of vaccinees to infection (infection-enhancing antibodies) while diminishing the susceptibility of the unvaccinated (infection-mediated training of innate cell-mediated immunity).

  • In the pre-Omicron era, we saw more infectious variants becoming dominant; however, thanks to the neutralizing antibodies, vaccinees were still protected against disease. However, with the advent of Omicron and its growing resistance to neutralizing antibodies, vaccinees became more susceptible to infection; what we are now seeing is more virulent variants becoming dominant  (Omicron subvariants BA.4 and BA.5[1]). however, thanks to the virulence-neutralizing antibodies (which are the same as those enhancing infection at the upper respiratory tract!), vaccinees were still protected against severe disease (e.g., in case of BA.1 and BA.2). I’ve no doubt, however, that with the growing resistance of BA.4 and BA.5 to the virulence-neutralizing Abs, vaccinees will now rapidly become more susceptible to virulence.  
  • Due to repetitive activation of the immune system in C-19 vaccinees, several infectious diseases can now be spread asymptomatically by vaccinees. Due to widespread asymptomatic transmission in highly vaccinated countries and the subsequent rise in infectious pressure, infection-mediated immunity in certain subsets of the population no longer suffices to prevent productive infection. This is now basically igniting the global spread of a number of acute, self-limiting microbial infections (e.g., ‘seasonal’ Flu, RSV but also vaccine-preventable viral and bacterial infections in countries that interrupted their childhood vax program due to Covid crisis) and also of some acute, self-limiting viral diseases (e.g., monkeypox, pandemic [avian H5N1] flu). In addition, depletion of cytotoxic CD8 T cells due to repetitive cycles of re-infection has also led to an increased recurrence/reactivation rate of chronic infections (e.g., herpetic diseases + CMV, EBV, CMV, HIV, tuberculosis..) and relapse or metastasis of certain cancers in vaccinees.
  • In the summary appended, I am sharing my informed predictions on the health impact these pandemics will entail in different subgroups of a highly vaccinated population. While these new pandemics are developing, the super C-19 pandemic I’ve been warning about is coming our way soon. In highly vaccinated countries, it will definitely overhaul the pandemics mentioned above. This is because massive replacement of ‘natural infection-acquired’ immunity to SC-2 by ‘imperfect’ vaccine-induced immunity is now driving the evolution of the C-19 pandemic in highly vaccinated countries. This will not be the case in poorly vaccinated countries where natural immunity has been largely preserved and the population is often much younger (e.g., African countries).

Last, I’d like to repeat my advice:

·      If you’re C-19 vaccinated: Make sure you’ve access to antivirals and antibiotics and that you’ve established a contact with an MD you can trust.

  • If you’re not C-19 vaccinated: You should under no condition get the seasonal Flu shot as vaccination with inactivated Flu vaccines will dramatically increase the risk of catching ADEI in the event you get exposed to avian flu. Under no condition should you get a non-replicating smallpox vaccine.[i] Since surface proteins of smallpox (using cowpox as live attenuated immunogen) are different from those decorating monkeypox, and as the non-replicating vaccine primarily induces antibodies (Abs), you could expose yourself to a real risk of ADEI. However, C-19 unvaccinated people don’t need a smallpox jab at all (and they don’t need an avian Flu vaccine either – in case the industry comes up with a pandemic flu vaccine!)  regardless of whether they got the smallpox vaccine in the past. Training of our innate immune system against Coronavirus (i.e., SC-2) during the C-19 pandemic will not only provide strong innate immune protection against influenza virus and poxviruses but also against other glycosylated viruses causing acute, self-limiting infection (e.g., RSV, other common cold CoV). I can explain this, but that would take somewhat longer. Upon exposure to smallpox or avian Flu, a C-19 unvaccinated person who is in good health and experienced mild or moderate C-19 symptoms as a result of previous natural infection (‘thanks’ to the C-19 pandemic) may still get some mild illness but that’s it! This will just induce additional antibodies to fully protect you next time around, pretty much like a live attenuated viral vaccine does. There is even a high likelihood that there won’t be a ‘vaccine take’ when you become vaccinated with live attenuated smallpox as your trained NK cells may kick out the vaccinal virus right away.  However innate immune training against CoV (e.g., SC-2) will not protect against measles, mumps, rubella or varicella (M, M, R, V). So, I simply continue recommending you to vaccinate your child against these childhood diseases before local outbreaks/ epidemics occur. It’s never a good idea, and could be dangerous for the child, to get the MMRV shot during a situation of high infectious pressure. Also, it is not recommended to vaccinate older children / adults/ elderly with these live attenuated vaccines if they’ve not been vaccinated against those diseases before. So, those who didn’t receive these childhood vaccines and did not acquire natural immunity as a result of previous natural infection are at risk of contracting the disease in case of an outbreak.  
  • Unvaccinated elderly and vulnerable people (e.g., with co-morbidities) have a risk of contracting moderate to severe disease from Flu or RSV. The likelihood for developing severe disease increases when the innate immune system is weakened, especially in case of exposure to high infectious pressure (the latter could, for example, rapidly build up in areas of high population density such as nursing homes. I would, therefore, recommend removing your parent/ grand-parents from nursing homes ASAP.
  • Live attenuated smallpox vaccine will not work in C-19 vaccinees because host cells that are infected with vaccinal virus will be readily recognized and killed by cytotoxic CD8 T cells that are continuously activated due to the enhanced susceptibility of vaccinees to re-infection.
  • C-19 vaccination of children must stop immediately. Not only will the C-19 vaccines fully prevent innate antibodies from neutralizing the virus, but they will also irreversibly prevent the innate antibodies (in association with the virus) from educating the cell-based innate immune system (e.g., NK cells). Instead, the vaccinal antibodies will enhance viral infectiousness and enable the virus to blow straight through the innate immune defense, thereby causing severe C-19 disease. It will also prevent the child from educating its innate immune system (a corner stone of natural immunity!) to recognize several other (glycosylated) pathogens while discriminating those from self-antigens. This could lead to severe disease caused by several other (glycosylated) pathogens which the child has not been vaccinated against as well as to severe immune pathology! It will also no longer be possible to vaccinate children with other live attenuated childhood vaccines once they’ve gotten the Covid-19 shot for these vaccines could now cause severe disease. So, the C-19 vaccine could be a death sentence for a young child!

You’ll find more details on these recommendations highlighted in the full manuscript I am still working on.

As far as the evolution of the C-19 pandemic is concerned, this is what you need to track if you want to know when the super C-19 pandemic is about to kick off:

When the ratio of the vaccinated to unvaccinated people in the age group 10-60 years old, who are hospitalized because of Covid-19, starts to rapidly increase, we will know that the super C-19 pandemic has begun. That’s the most sensitive criterion!

My heart goes out to the vaccinated people. The only way to bypass the malicious C-19 priming is to properly educate the vaccinee’s innate immune effector cells in the absence of replicating virus. It will be critical to treat them as of the early onset of symptoms. Treatment with antivirals shortly after infection could possibly train their innate immune system without boosting their infection-enhancing antibodies[2].

[1] https://www.biorxiv.org/content/10.1101/2022.05.26.493539v1.full.pdf

[2] https://www.voiceforscienceandsolidarity.org/scientific-blog/q-a-17-what-advice-could-one-offer-to-vaccinees-in-the-event-that-an-immune-escape-sars-cov-2-variant-adapts-to-the-highly-vaccinated-population-such-as-to-enable-high-infectiousness-combined-with-high-virulence

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[i] For more info on approved replicating and non-replicating smallpox vaccines: https://www.bavarian-nordic.com/pipeline/mva-bn.aspx;https://www.cdc.gov/smallpox/clinicians/vaccines.html

The original article can be found on TSN TrialSite News https://www.trialsitenews.com/a/immuno-epidemiologic-ramifications-of-the-c-19-mass-vaccination-experiment-individual-and-global-health-consequences.-1935ddcf

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Geert Vanden Bossche received his DVM from the University of Ghent, Belgium, and his PhD degree in Virology from the University of Hohenheim, Germany. He held adjunct faculty appointments at universities in Belgium and Germany. After his career in Academia, Geert joined several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development.

Geert then moved on to join the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer; he then worked with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness.

Back in 2015, Geert scrutinized and questioned the safety of the Ebola vaccine that was used in ring vaccination trials conducted by WHO in Guinea. His critical scientific analysis and report on the data published by WHO in the Lancet in 2015 was sent to all international health and regulatory authorities involved in the Ebola vaccination program. After working for GAVI, Geert joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office. He is at present primarily serving as a Biotech / Vaccine consultant while also conducting his own research on Natural Killer cell-based vaccines.

Email: info@voiceforscienceandsolidarity.org

Jul 2 2022

Lab Leak theory gets HUGE boost from WHO Chief in secret report | Redacted with Clayton Morris


By Redacted News  originally Published on Rumble on June 26, 2022

A whistleblower is calling out the origins of Covid as a lab leak. Is this anti-China propaganda or a fault of the World Health Organization? Who is undermining WHO?

Jun 26 2022

Woke Corporations Offering Relocation and Travel Cost Services for Employee Abortions


Posted originally on the conservative tree house on June 25, 2022 | sundance 

Yesterday we noted one of the likely downstream consequences from the Supreme Court decision on Roe might be that increased federalism and state control over abortion laws would lead to national ‘red lining.’  Essentially, leftists would avoid red state abortion restrictions and self-isolate in deepening blue regions where abortion is more common and accessible.

Within hours of that prediction, Google Inc sent an internal memo to employees offering to pay relocation assistance for any worker who would want to leave an area where abortion is likely to be restricted.

VIA NBC –  Google sent a companywide email Friday about the historic Supreme Court ruling overturning Roe v. Wade, explaining employees in affected states can apply for relocation without explaining why.

“This is a profound change for the country that deeply effects so many of us, especially women,” wrote Google Chief People officer Fiona Cicconi in an email to workers, viewed by CNBC. “Googlers can also apply for relocation without justification, and those overseeing this process will be aware of the situation.”

The note doesn’t say how many requests the company would approve and makes no promises. The company is still in the process of assigning relocations for employees who don’t want to come back into their assigned physical office due to the company’s return-to-office policy, which began in April.

Google has more than 30 locations across the U.S.  Cicconi also said it will be providing “support sessions” to employees in the coming days. (read more)

Assuming Google does not want to face lawsuits; and taking them at their word about no justification being needed; it would appear the reverse scenario is also true.  Google employees who work in an area of extreme leftism (deep blue), can ask for relocation to an area with a more conservative perspective (deep red).   This will be interesting to keep watching.

Additionally, Variety has compiled a list of several companies that will now pay health benefits to employees to travel out of state or region and terminate their pregnancy via abortion.

VARIETY – Disney, Netflix, Paramount, Comcast, Warner Bros. Discovery, Sony, Meta and several major media and entertainment companies said they will cover travel costs for employees seeking abortions after the Supreme Court overturned Roe v. Wade.

In the wake of the ruling, Disney reached out to employees on Friday to stress that they recognize the “impact” of the Supreme Court’s decision and “remain committed to providing comprehensive access to quality and affordable care” for all Disney employees and their families, which includes family planning and reproductive care, “no matter where they live,” an internal source told Variety.

For Disney employees unable to access a medical service, including abortions, in one location, they have a travel benefit that allows for “affordable coverage for receiving similar levels of care in another location.” Walt Disney World, one of the company’s major theme parks is located in Orlando. Florida Gov. Ron DeSantis has already moved to implement abortion restrictions that limit access to the procedure.

[…] Paramount Global CEO Bob Bakish and chief people officer Nancy Phillips sent a memo to staff on Friday, obtained by Variety, confirming the company’s intentions to cover travel costs for employees seeking abortions, writing, “Reproductive health care through company-sponsored health insurance, including coverage for birth control, elective abortion care, miscarriage care and certain related travel expenses if the covered health service, such as abortion, is prohibited in your area.” (read more)

Hopefully the most radical leftists will now self-isolate and stop migrating to regions where traditional American values are being retained.  This would be a natural outcome if the actions of the left-wing democrats were to match their rhetoric.  Unfortunately, I fear the abortion issue is not as big a political issue as the megaphones in media would like to believe.  Recent polling has shown very little political benefit in/around the issue of abortion.

It would be a good outcome if overturning Roe resulted in democrats stopping their migration away from their own left-wing policy madness; however, I’m not sure the abortion issue will overcome their desire to live outside of their insanity.   Leftists are ultimately the best representatives of cognitive dissonance when it comes to living up to their own ideological standards.

Democrats have long been known as “Blue Locusts” because they flee the totalitarianism and consequences they create; then seek to destroy the abundance they desire to have around them.  Modern leftists are dangerous in the destructive outlooks they carry.

If the Roe decision resulted in these leftists self-isolating away from conservative states, this would be of great benefit.  Alas, I doubt they are as committed to the issue as they claim.

If all the leftist democrats were to isolate themselves in geographic safe spaces, the non-breeding Moonbat population would decline and eventually disappear.   Unfortunately, I doubt we could be this lucky.